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In mammals, this long-standing metabolicepigenetic relationship appears to have become further refined to support complex developmental and environmental adaptation

Moreover, metal ions can also act in immunomodulation 25 , such as pathogen-host interactions 26,27 and cGAS-STING (cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes) signaling 28,29

It is known that probiotics secrete the most short-chain fatty acids, actic acid, butyric acid, and propionic acid

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