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doi: 10.1016/j.chom.2010.03.006 109 ZhangTYinCBoydDFQuaratoGIngramJPShubinaMet al

When homologous sequences meet structural decoys: accurate contact prediction by tFold in CASP14-(tFold for CASP14 contact prediction)

These drugs mediate the release of DAMPs following hepatocyte injury, which are sensed by, for example, Kupffer cells (KCs), activating innate immune receptors to trigger intracellular events leading to the release of pro-inflammatory mediators, cytokines, and chemokines, and then recruit neutrophils and monocytes to the blood in a sterile inflammatory process

Remarkably, a study by Escribano et al revealed that, when compared with the control group, children with severe AATD showed significantly increased levels of oxidative stress biomarkers and decreased levels of antioxidants, as expressed by lower total and reduced glutathione levels, decreased catalase activity, and increased glutathione peroxidase activity

Cai et al., 2023)