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Bowers C.Y

As with genomic DNA, mtDNA may also undergo nucleotide mutations that have been shown to be responsible for mitochondrial dysfunction

It may affect small, localised areas of the body, such as the scalp, arm, or leg, or it can spread to involve larger regions or even the entire body

Furthermore, the model assumes a fixed timeline for the control problem, which may not reflect the real temporal dynamics of disease progression and treatment response in individual patients

Both of these carnitine metabolites are known as serum biomarkers of preeclampsia and have been shown to increase under hypoxic conditions in a cultured placental choriocarcinoma cell line (the BeWo line) 30