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[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Monti D., Sotgia F., Cotzia P., et al

IGF2 interacts with the imprinted gene Cdkn1c to promote terminal differentiation of neural stem cells

The foundational study is Neelakantan and colleagues, 2018 , in Biochemical Pharmacology

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However, the activity of p53 is positively regulated by the alternative reading frame tumor suppressor (ARF), an upstream molecule that suppresses the MDM2 activity (73)