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In tolerance assay, at 42 h after the end of conditioning regimen, shorter preconvulsive latencies than in healthy (non-diazepam conditioned) mice following isoniazid (800 mg/kg i.p.) (as hallmark of tolerance) were observed if diazepam (5.0 mg/kg i.p.) was again given acutely to mice previously conditioned with diazepam alone (use of picrotoxin 3.0 mg/kg i.p., as convulsant, with acute application of diazepam in previously diazepam conditioned mice did not lead to tolerance hallmark)

acute metabolic disturbance

This is the same general system that benzodiazepine drugs like diazepam target, but Selank acts differently: it modulates and stabilizes the system rather than flooding it, resulting in reduced anxiety without sedation or loss of cognitive sharpness

The consequences can be devastating