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Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation [7]

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Notably, outliers detected both at PRE-START and at the time of DARA treatment failure pointed to biologically distinct, potentially genetically driven MM subgroups with divergent therapeutic responses ( Figure 5 ) confirmed consistent detection of ADO and INO but revealed divergent dynamics, highlighting the need for personalized metabolic monitoring

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