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Ahamed K, Epaud R, Holzenberger M, Bonora M, Flejou J-F, Puard J, et al

The uniform placement of Fe and Mn atoms in the structure indicates the generation of Fe and Mn double sites in the three-dimensional matrix

This inhibition also causes AKT dephosphorylation and dysfunction

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Collectively, cytochrome c release and caspase activation driven by iron-induced ROS are the common routes for the activation of intrinsic apoptosis and pyroptosis, while the suppression of short Fas by iron is a common route for the activation of extrinsic apoptosis and necroptosis