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METH transit across the BBB damages the nucleus accumbens shell region and prefrontal cortex and causes hyperthermia, neuroinflammation, and brain edema (Zhang et al., 2017)

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the nucleic acid associated with a lipid may be encapsulated in the aqueous interior of a liposome, interspersed within the lipid bilayer of a liposome, attached to a liposome via a linking molecule that is associated with both the liposome and the oligonucleotide, entrapped in a liposome, complexed with a liposome, dispersed in a solution containing a lipid, mixed with a lipid, combined with a lipid, contained as a suspension in a lipid, contained or complexed with a micelle, or otherwise associated with a lipid

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Collectively, these findings establish a TRPV1-dependent thermogenic program in adipose tissue, providing a mechanistic framework for interpreting human studies in which dietary capsaicin or capsinoids modestly increase energy expenditure, particularly in individuals with metabolically active brown adipose tissue (2023)