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Both interventions target aspects of metabolic health, which has led to interest in whether their combination might enhance outcomes beyond what either achieves alone

Absorbance at 450 nm was measured using a Spark Multimode Reader (Tecan, Mnnedorf, Switzerland)

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Mitophagy (termed mitochondrial autophagy) is a selective autophagic process that targets dysfunctional or redundant mitochondria through stress-responsive mechanisms

Von Hippel-Lindau disease is a hereditary tumor syndrome and about 30%-70% of patients with VHL develop RCC, and VHL-related renal cell carcinoma is almost ccRCC