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Oral administration faces substantial hurdlesacidic gastric milieu, digestive enzymes, rapid mucus clearance, and heterogeneous lesion distributionleading to suboptimal on-target exposure

Certainty of evidence: C Strength of recommendation: Strong

Second, the binding interface between RanBP1 and Ran-GTP weakens the importin :Ran-GTP binding interface at contact point c (red dashed line in Fig

Acknowledgements The authors sincerely thank the Alliance of International Science Organizations (ANSO) for generously awarding a scholarship to the first author, and Wuhan Metware Biotechnology Co., Ltd for their support with sequencing