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The broad-spectrum inhibitor -CHCA reduces lactate export and sensitizes tumor cells to chemotherapeutic agents in preclinical models 159,160

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Scd1 (F: GCTGGAGTACGTCTGGAGGAA, R: TCCCGAAGAGGCAGGTGTAG)

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Collectively, this study identifies GGCT as a metabolic switch that diverts Gln flux toward GSH synthesis to maintain redox homeostasis, while enhancing glucose-fueled anaplerosis into the TCA cycle to sustain cell proliferation