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As oxygen is scarce, most of the pyruvate is converted to lactate, instead of entering the tricarboxylic acid cycle (TAC)

For complete information about the updates to ONC health IT certification criteria finalized in the HTI-1 final rule, we refer readers to the text of the final rule (89 FR 1192) as well as resources available on ONC's website

However, increasing cell compliance or reducing matrix stiffness suppresses energetic costs, blinding MDA-MB-231 cells to hydraulic resistance and enabling them to navigate through high-resistance migratory paths that would otherwise demand more energy [201]

doi:10.1007/s00167-009-0953-3