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This may be explained by differences in body composition and should be taken into account when dosing or following factor VIII levels in the pediatric population.4 Because clearance (based on per kg body weight) has been demonstrated to be higher in the pediatric population, dose adjustment or more frequent dosing based on per kg body weight may be needed in this population [see Clinical Pharmacology (12.3)]

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650 Methyl ferulic acid inhibits the expression of NOX4 protein and alleviates neuropathic pain in mice by regulating the expression of ACSL4 and GPX4, as well as ROS and iron content, suggesting that inhibiting NOX4-induced ferroptosis can reduce neuropathic pain

Oxidative stress rises and can also trigger refractory epilepsy