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Astrocytes immediately respond to any form of CNS insult, exhibiting morphological and functional changes characterized by hypertrophy, enhanced expression of the glial fibrillary acidic protein (GFAP), the release of inflammatory mediators, and the synthesis of neurotrophic factors (Abbracchio and Ceruti, 2006)

B., Finney, L., Vogt, S., Witting, P

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