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For all these reasons, neurotrophins such as BDNF have attracted much attention for their neurotrophic and neuroprotective properties in central nervous system and have been used for therapeutic treatment of a range of neurodegenerative disorders including Alzheimers disease

2022;119: e2201899119

Higher rates require a central line placed in a large vein and continuous heart monitoring

At timepoint 360 min, we observed a pronounced drop in both fully labeled glucose and lactate in iPSCs, most likely reflecting depletion of the extracellular glucose supply (5 mM) in the medium, which may have contributed to the onset of gluconeogenesis, highlighting a metabolic adaptation in response to nutrient availability [67]