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Basing that, we assumed this discrepancy stemmed from the inability of co-culture system in vitro to fully simulate in vivo cellular communication dynamics, and which may be caused by the low concentration of interleukins from original pyroptotic hepatocytes in the co-culture system, which was insufficient to drive M1 polarization of macrophages

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Indeed toxicity studies showed a lethal dose of LD50 greater than 10 g/kg in mice, without carcinogenic or teratogenic effects at dosages of 1.5 g/kg per day (157, 158)

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This may hint at what lies ahead as we navigate the (mostly erroneous) tendency to identify every cell death process in drug hepatotoxicity and other liver diseases as ferroptosis