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Description

PARP-1 is a member of the PARP enzyme family consisting of PARP-1 and many additional poly-(ADP-ribosylating) enzymes

Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimers disease

Bio/Technology

Our research team previously demonstrated that the estrogen/GPER/PKA signaling axis in cancer-associated fibroblasts (CAFs) within triple-negative breast cancer mediates the synthesis and secretion of lactic acid and glutamine, exacerbating the metabolic remodeling of breast cancer and leading to multidrug resistance in tumor cells [227, 243], a process known as the reverse Warburg effect

The DN-RAGE form has the extracellular (V- and C-type regions) and transmembrane domains like fl-RAGE, but lacks the intracellular cytoplasmic domain required for initiating downstream signaling