Key regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) mice
Some of the limitations of our study are the small sample size, resulting from non-compliance and study drop-out during the rise of the global COVID-19 pandemic
Advances in Experimental Medicine and Biology, vol 681
2022 doi: 10.3389/fimmu.2022.1004545/full
pylori associated dyspepsia ( To facilitate the management of FD, the Rome Consensus subdivided FD into two subtypes: Postprandial Distress Syndrome (PDS) (60%) characterized by meal-related symptoms, such as postprandial fullness, early satiation, postprandial epigastric pain and other symptoms triggered by food ingestion, and Epigastric Pain Syndrome (EPS) (20%) characterized by epigastric pain and burning ( FD is extremely common, with estimates of 1030% prevalence in the general population, and is associated with substantial medical care costs and a considerable health economic impact ( Finally, FD patients also show an important degree of overlap with gastro-esophageal reflux disease (GERD) ( Gastroparesis Gastroparesis is characterized by delayed gastric emptying and by upper gastrointestinal symptoms (nausea, vomiting, abdominal pain, early satiety, bloating) in the absence of mechanical obstruction ( Gastrointestinal Peptides In the classical pathophysiological model, functional gastrointestinal disorders (FGIDs) are considered heterogeneous conditions, and symptoms are attributed to a combination of motility disturbances, visceral hypersensitivity, low grade mucosal immune activation, and altered processing of gut-brain signals ( Recent research has focused on visceral hypersensitivity as a common mechanism determining symptom severity and impact across several functional gastrointestinal disorders ( The gastrointestinal mucosa expresses a wide range of chemosensing receptors, which detect the presence and nature of nutrients in the lumen ( There is recent evidence of nutrient-specific enhanced release of gut peptide hormones [motilin, ghrelin, peptide YY (PYY), cholecystokinin (CCK), and glucagon-like peptide 1 (GLP-1)] in FD, which was correlated to intensities of the provoked symptoms
