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Time-to-onset analysis of NAEs associated with GLP-1 RAs The median time-to-onset of NAEs for all GLP-1 RAs was 31 days (interquartile range [IQR] 7123), with 46.25% occurring within the first 30 days of treatment initiation (Table S6, Figure S2)

Prodrug-based Nano-DDS (PNDDS), which combines prodrug and nanotechnology strategy into a single system, has emerged as significant and discernible trend in recent years to conquer related limitations about conventional drug for nanomedicine therapy [37,38,39,40,41,42]

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