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Nelson DB, Niu J, Mitchell KG, Vaporciyan AA, Hofstetter WL, Antonoff MB , Giordano SH, Sepesi B, Mehran RJ, Rice DC

In ALI, mitochondrial dysfunction contributes to impaired cell bioenergetics and heightened oxidative stress

Signal sensitivity pulsed dosing is the conservative way to avoid blunting the response over time

Notably, these elevated levels were markedly attenuated by marmelosin treatment

Introduction In the past few years, greater understanding of the pathogenesis of SLE has translated into the development of more targeted therapeutic agents in various stages of clinical trials