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Importantly, this death mechanism differs from apoptosis, necroptosis and ferroptosis, as evidenced by insensitivity to their inhibitors and absence of classical markers like caspase-3 cleavage, cystine crystal formation or ATP depletion (Liu X

This study is limited by the heterogeneous interventions, dose regimes, limited sample sizes and evaluation methods which hindered the possibility of an objective statistical analysis

However, emerging drugs that target the main autoantigen (monoclonal antibodies, small molecules, peptides) or block the immune pathway have been recently tested in clinical trials

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Pharmacognosy and pharmacology of Calotropis gigantea for discovery of anticancer therapeutics