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Statements Data availability statement The original contributions presented in the study are included in the article/ Supplementary Material , further inquiries can be directed to the corresponding author/s

Hazard ratio (HR) estimates were calculated using a Cox proportional hazards model with effect for treatment

BRD4 ET sample (0.2 mM) was placed in the cell, whereas the micro-syringe was loaded with the ASXL1 peptide (2.0 mM) in the ITC buffer

(142) confirmed that CSF1R inhibitor Pexidartinib (PLX3397) could effectively inhibit the activation of pERK1/2 signaling molecules by CSF-1, resulting in decreased polarization, survival and chemotaxis of TAMs

doi: 10.1039/C8LC00357B 112 DornhofJKieningerJMuralidharanHMaurerJUrbanGAWeltinA