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336 The age-dependent decline of NAD + might be due to either enhanced consumption or reduced biosynthesis

targeted the IP3 receptor (IP3R) channels and induced the downstream pro-apoptotic Ca 2+ -signaling pathway via synthesizing a peptide named Bcl-2 IP3 receptor disrupter-2 (BIRD-2) mimicking the structure of the BH4 domain of Bcl-2

This led directly to the SYNERGY liver disease trials

Sharma A, Rudrawar S, Bharate SB, Jadhav HR (2024) Recent advancements in the therapeutic approaches for Alzheimers disease treatment: current and future perspective

In further embodiments, the invention encompasses a method of treating an NNMT-expressing cancer, such as glioblastoma, by administering a therapeutically effective amount of one or more cations chosen from Tables 1, 2, 3a, and 3b