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doi: 10.1016/j.lfs.2023.122145 42 BaHammamASPirzadaA

A precise human half-life figure from a published human PK study is not something this review can cite with confidence

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The transcription and expression of the antioxidant protein glutathione peroxidase 4 (GPX4), as well as mitochondrial function-associated proteins ATP synthase subunit alpha (ATP5A), ubiquinol-cytochrome c reductase core protein 2 (UQCRC2), and cytochrome c oxidase subunit I (MTCO1), were also restored following irisin treatment (Fig