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Int J Mol Sci 22 (2021)

Combined toxicity of polyethylene microplastics and nickel oxide nanoparticle on earthworm ( Eisenia andrei ): oxidative stress responses, bioavailability and joint effect

Design issues include study objective, availability of data, sampling methods, data collection, cost of the design, time implications, controls, and ethical considerations (Wang and Kattan 2020)

BCATs are the first enzymes in the BCAAs metabolic pathway, including BCAT c encoded by BCAT 1 gene, mainly expressed in the cytoplasm, and BCAT m encoded by BCAT 2 gene, which is expressed in the mitochondria