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Nevertheless, various stimuli such as chronic disease states, metabolic conditions (e.g., type 2 diabetes mellitus [T2DM], obesity, dyslipidemia), smoking, and disturbed blood flow can disrupt such a quiescent phenotype and lead to endothelial cell dysfunction (ECD) (Fig

5.5.2 Cyclodextrin (CD) CD is a water-soluble, biodegradable cyclic oligosaccharide that produces a mixture of -CD, -CD, and -CD composed of 6, 7, and 8 glucopyranose units, respectively

RNA m(6)A regulates transcription via DNA demethylation and chromatin accessibility

96 It has been shown that hepatocellular carcinoma cells are resistant to sorafenib, a novel multi-targeted oral drug for the treatment of tumors, 97 which is acquired through transcriptional regulation of genes involved in lipid ROS and iron metabolism