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Acquisition and synthesis of xenobiotic glucuronides Compounds 1 , 4 , 12 , 17 , 18 and morphine-3-glucuronide were purchased from Sigma Aldrich

For fatty acid measurements, chloroform phase containing TG-bound fatty acids was hydrolyzed using alkaline hydrolysis

FIGURE 5 TABLE 4 E max (g/f) and p EC 50 values of CCh in rat tracheae of the CG, AG, and ALA25G in the absence and presence of apocynin

Mild ischemia (CBF greater than 30 ml/100 g/min) does not normally cause cell death during the first 6 h after injury, moderate ischemia (CBF between 12 and 30 ml/100 g/min) reaches the threshold of viability in 3 h, and severe ischemia (CBF lower than 12 ml/100 g/min) causes cell death in less than an hour (Sakoh et al., 2000)

Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery