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Lastly, although the following genes are implicated in AD at late stages, we did not find differences between Wt and Tg expression of Ape1 137,138 , Cdk5 137,139,140,141,142,143 , Parp1 105 , Pcna 144,145 , Pol 146,147 , or Sirt3 148,149,150 ,