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Enhance fat metabolism through greater utilization of stored fatty acids
miR-34c-5p, miR-375, and miR-449c-5p are consistently downregulated, whereas miR-205-5p, miR-92a-3p, miR-193b-3p, and miR-27a-5p are upregulated, and their predicted targets include cell-cycle regulators (p53, CCND1, CDK6), pro-survival mediators (MET, BCL2), and extracellular matrix remodelers (MMP1/3, PLAU)
Each cycle can be divided into two main phases the follicular phase and the luteal phase with ovulation marking the transition between them
Thus, activation of AMPK modulates the miR-206/HDAC4/cyclin D1 signaling pathway, chiefly targeting HDAC4, to suppress airway smooth muscle cell proliferation and, therefore, has potential value in the prevention and treatment of asthma by alleviating airway remodeling
Depner et al., 2013
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