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Consistent with this, treatment of mice with the PARP-1 inhibitor PJ34 downregulates hepatic M1 marker gene expression (14)

Conventional copper-modulating therapies, including chelators (e.g., TTM and TETA) and the ionophore elesclomol, are fundamentally limited by their lack of specificity, which constrains their clinical utility and leads to significant adverse effects

The increase of -H2AX adds to the hypothesis that HnB may be associated with DNA-damaging activity

However, HF-SAAR raised the levels of short-chain acylglycines (acetylglycine, isobutyrylglycine, and isovalerylglycine) in the liver (Fig

At low doses, QUE exhibits antioxidant and anti-inflammatory effects, as demonstrated in a study where a low dose (10 mg/kg) reduced pro-inflammatory markers (TNF- and IL-1) in rats with doxorubicin-induced nephrotoxicity