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Investigations into exosome therapy for POF are predominantly in the preclinical phase, with encouraging outcomes in enhancing ovarian function through the mitigation of oxidative stress and apoptosis, as well as the stimulation of angiogenesis and follicle maturation (Kim and Kim 2024

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10.1074/jbc.M113.493023 24 BernatchezP.SharmaA.BauerP

In turn, the diminished glutathione level, being the major reservoir of non-protein reduced sulfur, may be the source of the decreased level of this element observed in the spleen for female rats