In conclusion, investigating the comorbidity of chronic constipation and depression from the MGBA perspective would contribute to a deeper understanding of disease pathophysiology and provide scientific evidence for developing innovative diagnostic and therapeutic strategies, with the potential to contribute significantly to improving patient outcomes, enhancing quality of life, and reducing healthcare burdens
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Methimazole is metabolized through cytochrome P450 (CYP) enzymes35,36 and flavoprotein mixed-function oxidase (FMO).37,38 Methimazole metabolism through CYP450 enzymes gives N-methylthiourea and glyoxal as two major metabolites.36 Nmethylthiourea is further oxidized with FMO enzyme to give sulfinic and sulfenic acid species.38 Glyoxal, is a reactive compound capable of interacting with different intracellular targets, such as proteins.39 Sulfenic acids are high electrophilic species that form irreversible adduct with cellular nucleophilic sites,40 and may have a role in methimazole-induced hepatotoxicity
Finally, a prospective cohort study including 7438 mother-child pairs, investigated whether a maternal anti-inflammatory diet reduced the risk of prenatal environmental adversity (PEA)-induced neurodevelopmental delay
BrinjikjiWKallmesDFVirmaniRde MeyerSFYooAJHumphriesWet alEndotheliitis and cytokine storm as a mechanism of clot formation in COVID-19 ischemic stroke patients: a histopathologic study of retrieved clots
