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Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

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Phase 2a MASH data showed significant liver fat reduction

Complex IV, Cytochrome c oxidase

Brain-derived Neurotrophic factor ( BDNF ) is essential for neurogenesis and extensively studied as a biomarker in psychiatry (Lin & Huang, Reference Lin and Huang2020) There is extensive evidence of a difference in DNAm in BDN F, as well as EWAS studies showing enrichment for the neurogenesis pathway in SCZ (Di Carlo et al., Reference Di Carlo, Punzi and Ursini2019