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Of note, TMAO in the pathogenesis of Alzheimers disease (AD) indicated that PERK is not the only mechanism by which TMAO induces UPR

In a pediatric study of involving 180 children with AD and 242 healthy controls, vitamin E levels were found to be inversely associated with AD prevalence ( A study assessed the influence of maternal diet during pregnancy in a population comprising 557 motherchild pairs and showed that inadequate vitamin E intake during pregnancy was correlated with an increased risk of AD (OR = 2.7, p = 0.04) ( In a double-blind, randomized, placebo-controlled study, Jaffary et al