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-Glutamylcysteine exhibits anti-inflammatory effects by increasing cellular glutathione level

The exact molecular mechanism by which creatine exert its neuroprotective effect is not clearly understood

In an in vivo study, after intravenous administration of modified MNTs with polyethylene glycol into mice with Cloudman S91 melanoma, it revealed improved accumulation in the tumor site [111]

Reduced electron flow through complexes I and III slows downstream OXPHOS, leading to substrate accumulation and impaired metabolic flexibility ( AMP-activated protein kinase (AMPK) plays a critical but context-dependent role in this process (Qi and Young, 2015)

Wan W, Cao L, Liu L et al (2015) A(1-42) oligomer-induced leakage in an in vitro blood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins