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Currently, two major hypotheses prevail in terms of FLC and ALC development and differentiation

However, significant challenges remain in translating metabolomic findings into clinical practice, including the standardization of analytical protocols, cross-population validation, and the biological interpretation of complex datasets

1,4,6 In addition, a number of integrative interventions have been identified as having protective effects on brain function

This Research Topic aims to highlight recent advancements and challenges in MS-based adductomics within biological matrices, and further adductomic approaches to the study of the exposome in health and disease

Under physiological conditions, a healthy gut microbiota and an intact intestinal barrier are critical for establishing immune tolerance ( The tumor immune microenvironment (TIME), a dynamic ecosystem of cancer cells, stromal cells, ECM, and diverse immune cells, profoundly shapes tumor progression and therapeutic responses ( A pivotal mechanism linking gut dysbiosis to pro-tumorigenic inflammation is the translocation of microbial components, most notably lipopolysaccharide (LPS), across a compromised intestinal barrier ( Beyond TLR-dependent microbial sensing, the NF-B pathway serves as a critical signaling hub that integrates diverse pro-tumorigenic stimuli within the TIME