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In 8 out of 10 countries investigated in that study (Vicedo-Cabrera et al., 2018), the fraction of deaths attributable to heat declined over time, and this decline was due mostly to decreased sensitivity to heat (i.e., not local cooling)

For example, manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant enzyme, can undergo nitration of its tyrosine residues, leading to enzyme inactivation and contributing to oxidative stress and related diseases

The assay of catalases and peroxidases

Paradoxically, this event does not decrease mGSH in cancer cells because of the adaptive overexpression of 2-oxoglutarate transporter (2-OGC or SLC25A11) through hypoxia-inducible factor-1 (HIF-1) stabilization [125, 126, 152]

Doctors usually treat iron deficiency anemia with dietary changes and iron supplement pills