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This suggests that any inflammatory reactions independent of the stimulus, theoretically, could have the potential to lead to the development of FISS through triggering uncontrolled proliferation of fibroblasts and myofibroblasts, which, in some cases, results in malignant transformation

Gastrointestinal side effects such as nausea, vomiting, and diarrhoea can lead to fluid and electrolyte losses, potentially triggering muscle cramps

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Am J Vet Res , 2002

Not because oral dosing is impossible, but because the compound's pharmacokinetic profile makes oral bioavailability unreliable for controlled studies