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Parameters to monitor Serum electrolytes (especially creatinine and potassium) Symptoms of angioedema BP Symptoms of hypotension CBC (especially with captopril and enalapril) for neutropenia, which is more common in patients with preexisting renal impairment Cough Urinary proteins Direct Renin Inhibitors See Table 12-16 for a list of direct renin inhibitors, their usual dosage range, and adverse effects associated with these medications

These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005