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[Abstract]2021 Aug 18:2021:5451758

Our improved understanding of the complex biological regulation of appetite, metabolism and body weight, involving co-ordinated responses between peripheral tissues and central appetite-regulating centres, has resulted in the availability of nine Food and Drug Administration (FDA) (liraglutide, semaglutide, tirzepatide, orlistat, phentermine, phentermine/topiramate, bupropion-naltrexone, setmelanotide, and metreleptin), and seven European Medicine Agency (EMA) (excluding phentermine and phentermine/topiramate), approved AOMs

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doi: 10.1007/s13277-014-1859-3 257 WeiLWuNWeiFLiFZhangYLiuJet al

Tacrolimus: A prospective study in healthy Chinese volunteers (N=9) with CYP3A5 expressers showed a 2.5-to 4-fold increase in tacrolimus exposure when concomitantly administered with amlodipine compared to tacrolimus alone