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While retinoids can significantly improve the appearance of enlarged pores, mild acne scars, and fine lines, most patients with moderate to severe acne scars require in-office treatment options to achieve a smoother complexion and even skin texture

Among these, NLC had the smallest size, NLC, and LNE showed maximum bioaccessability, and LNE achieved controlled and maximum release [209]

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Wang, Y., Yu, Z., Zhang, Z., Ren, R