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Scaling concepts in omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis

It is due to the inactivation of the glutathione (GSH)-dependent antioxidant defense mechanism in cells, and the ability of GPX4 to suppress lipid ROS accumulation is inhibited, which eventually leads to lipid peroxidation and cell death (Dixon et al., 2012)