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Cytokines secreted by activated macrophages can also interfere with myelination and the expression of related genes (247), preventing myelin sheath repair and causing disability (248)

10.3390/cancers12010164 Cancers 9 BjrklundG.TinkovA.KizekR.AjsuvakovaO.ChirumboloS.SkalnayaM.et al (2020)

Together, these interconnected pathways establish a self-perpetuating cycle that accelerates biological aging

These findings have led to the consensus that elevated plasma total homocysteine is a modifiable risk factor for development of cognitive decline, dementia, and Alzheimers disease in older persons