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Selective Gsto2 knockdown prevents the early and late onset of motor symptoms in Trkb Penk -KO mice Penk -KO The above results suggest that disrupted TrkB signalling in iSPNs affects GSHascorbate metabolism, particularly GSTO2, which impacts the DA system and thus energy metabolism

JP: Writing original draft, Methodology, Supervision, Writing review & editing, Data curation, Visualization, Conceptualization, Investigation, Validation