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Functional studies have further revealed that keratinocyte-specific VDR knockout (VDRKO) mice exhibit markedly delayed re-epithelialization following skin injury, accompanied by impaired migration and activation of follicular and epidermal stem cells [226]

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To further investigate the mechanism underlying STAT3 downregulation, we examined the protein expression levels of its upstream signaling molecule, JAK2, and phosphorylated JAK2 (p-JAK2)