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To investigate whether NAM upregulates the expression of ROS-detoxifying enzymes through PGC1A, MC3T3-E1 cells were treated with small interfering RNAs (siRNAs) targeting Pgc1

The ability of HO-1 to protect against SARS-CoV-2 infection is probably an emergency inducible defense mechanism to ameliorate OxS from heme-released oxidants 27