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Similar content being viewed by others Introduction Long-term excessive energy causes the expansion of adipose tissue (AT), ultimately leading to overweight and obesity [1]

This process links to age-related cardiovascular changes, where ROS from NOX enzymes oxidize lipids and proteins, accelerating vascular stiffness and dysfunction

Adverse health effects have been observed at both extremes of intake, with a narrow optimum range

Tesofensine has been shown to be much safer than other existing weight-loss drugs when considering potential side effects such as high blood pressure, heart rate changes and sexual health problems

The transfer of persulfur to the ISCU2 scaffold seems to be mediated by frataxin (Fox et al., 2015)