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Another clinical study of 71 women with mild to advanced signs of photoaging who applied GHK-Cu facial cream daily for 12 weeks showed increased skin density and thickness while reducing sagging and the appearance of fine lines and wrinkles

[DOI] [PMC free article] [PubMed] [Google Scholar] 244.Acevedo MB, Teran-Garcia M, Bucholz KK, Eagon JC, Bartholow BD, Burd NA, Khan N, Rowitz B, Pepino MY

The upregulation of spermidine in the circulating system might contribute to the remission of MS in an undefined manner

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Such helical changes could dramatically alter repressor (or activator) binding and gene function