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doi: 10.1080/21655979.2021.1964158 140 WangCYBabittJL

Although absorption is slower compared to IM injections, this method remains highly effective

Its primary mechanisms include promoting angiogenesis (new blood vessel formation) through VEGF upregulation, modulating the nitric oxide system in a context-dependent manner, activating the FAK-paxillin pathway to drive cell migration and tissue rebuilding, and regulating multiple growth factors (PDGF, TGF-beta, FGF) involved in organized tissue repair