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FIGURE 1 The levels of cellular nutrients (amino acids, glucose, certain lipids, and likely other metabolites) are sensed and signaled by an expanding number of proteins (SESNs, CASTOR, KICSTOR, SAMTOR, GATOR1 and 2) (Saxton and Sabatini, 2017) that culminate in the control of the guanosine phosphate state of the members of the Rag family of GTPases, which bind mTORC1 in a nutrient-sensitive manner (Figure 1)

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In addition to their obvious benefits in terms of pharmacokinetics, blood circulation time, and medication toxicities, nanomaterials also enable targeted drug delivery, slow drug release, and increase drug solubility

The colored surface (obtained by a trilinear interpolation from the three nearest electrodes) represents the effect size (see Materials and Methods for details)